Journal: Science Advances
Article Title: A robust adhesive microneedle for oral infections therapy via synergistic antibacterial and neutrophil-macrophage axis immunomodulation
doi: 10.1126/sciadv.aee4401
Figure Lengend Snippet: ( A ) 3D-FEA stress distribution maps of the peel adhesion behavior between the PCA@FeCO flat/MN patch and the mucosal tissue. ( B ) The peel, tensile, and shear adhesive strengths of PCA@FeCO flat and PCA@FeCO MN. Data are presented as means ± SD ( n = 4). ( C ) Schematic illustration of MN taper. ( D ) Stress distribution maps of the mucosal tissue from 3D-FEA of the peel adhesion behavior between PCA@FeCO MNs with different tapers and the mucosa. ( E ) Peak stress in the mucosa induced by PCA@FeCO MN with different tapers in the 3D-FEA model. ( F ) Peak stress of PCA@FeCO MN with different tapers in the 3D-FEA model. ( G ) Compression performance test of PCA@FeCO MN with different tapers. ( H ) Morphology and composition of 30°-PCA@FeCO MNs: Photograph, magnified view, SEM image, and EDS analysis. Among them, photograph and magnified view are the same as those in fig. S4. ( I ) Cross-sectional fluorescence images demonstrating the distribution of rhodamine B–labeled PCA@FeCO MN in mucosa after 10 min. ( J ) Robust adhesion of PCA@FeCO MN to the buccal mucosa, palatal mucosa, gingiva, and tongue of a rat.
Article Snippet: A 3D-FEA simulation was conducted in the ABAQUS software.
Techniques: Shear, Adhesive, Fluorescence, Labeling
